Elevated Lipid Peroxides

Chronically Elevated Lipid Peroxides are associated with premature aging and the eventual onset of deadly diseases such as cancer.  Schedule a FREE 20 minute consultation with me to discuss the use of functional lab testing to determine if you have elevated Lipid Peroxides.

Here is a link to an article that discusses a scientific study about Lipid Peroxides, but I’ve pasted the text of the article below for your convenience:

Lipid Peroxides: More Sophisticated Than Their Reputation

Aug. 24, 2010 — Accumulation of lipid peroxides in the cell are associated with diseases and cellular stress. In the current issue of Proceedings of the National Academy of Sciences, researchers at Helmholtz Zentrum München and the Swedish medical university Karolinska Institutet show that lipid peroxides also play an important, yet-unrecognized role in the regulation of receptor tyrosine kinases.

Neurodegenerative Diseases (DZNE) and a research group at Karolinska Institutet in Stockholm, Sweden, researchers have now discovered that lipid peroxides play a specific physiological role in the cell. Prior to this study, scientists had already established that accumulation of lipid peroxides indicate cell stress. Lipid peroxides have further been shown to be very potent inducers of cell death.

The results of this study now demonstrate that chemically modified (oxidized) lipids temporarily inactivate protein tyrosine phosphatases. These in turn regulate the cellular communication of receptor tyrosine kinases (RTK). This finding is of central importance because aberrant activation of the receptor tyrosine kinases contributes to many diseases, including cancer. Until now, only hydrogen peroxide was known to oxidize and inactivate protein tyrosine phosphatases and thus to have a regulating effect on kinases.

“We were able to show that lipid peroxides are 100-1000 times more effective than hydrogen peroxide,” said Dr. Marcus Conrad, lead authors of the publication, who has since moved from Helmholtz Zentrum München to the German Center for Neurodegenerative Disease. Dr. Arne Östman and Åsa Sandin from the Karolinska Institutet added: “It will be very interesting to see if lipid peroxides contribute to the activation of tyrosine kinases in cancer and other diseases, e.g. diabetes and Alzheimer’s disease.”

Background

Lipid peroxides are chemically modified lipids or fatty acids, which, among other things, indicate cellular stress. In high concentrations they can trigger cell death. Elevated concentrations of lipid peroxides are often found in patients with common diseases such as atherosclerosis, diabetes, cancer or neurodegenerative diseases including Parkinson’s and Alzheimer’s disease.

Receptor tyrosine kinases (RTK) and protein tyrosine phosphatases have an important function in the regulation of cell growth and division. Over-active receptor tyrosine kinases play a key role in the etiology of cancer. A frequent cause of breast cancer, for instance, is a malfunction of the receptor tyrosine kinase HER-2 (human epidermal growth factor receptor 2). In healthy tissues and cells receptor tyrosine kinases are precisely regulated by protein tyrosine phosphatases.

Understanding the causes and effects of chronic oxidative stress:

Abstract

Physical and emotional stress, metabolic alterations, carcinogenesis or inflammation are conditions that can trigger oxidative stress, which is defined as a balance shift of redox reactions towards oxidation, resulting in the increase of reactive oxygen species (ROS). ROS are continuously formed in small quantities during the normal metabolism of cell, however the overproduction of ROS is cytotoxic and damages macromolecules (DNA, proteins, sugars and lipids). Polyunsaturated fatty acids (PUFAs) that are esterified in membrane or storage lipids are subject to ROS-induced peroxidation resulting in the destruction of biomembranes. Final products of lipid peroxidation (LPO) are reactive aldehydes that are relatively stable and may diffuse far from the initial site of oxidative injury and act as second messengers or free radicals. The difference between physiological and pathological oxidative stress is often the occurrence of LPO and its final toxic products. In this chapter, two classes of methods for measurement of LPO are described. The first include assays for detection of LPO at the organismal level, while the second include molecular and cellular assays that reveal the mechanistic effects of LPO on the function, morphology and viability of the cells.

Well, tell us what you think! Leave a reply below: